📄 Category

cardiovascular medicine

131 papers

Cardiovascular medicine focuses on the heart and blood vessels, exploring how to prevent, diagnose, and treat conditions that affect our circulation. This vital field ranges from understanding high blood pressure and heart failure to investigating the latest breakthroughs in surgical techniques and lifestyle interventions. Because these discoveries directly impact public health, staying informed about emerging research is more important than ever for both specialists and curious readers.

At Gist.Science, we process every new preprint in this category as it appears on medRxiv, ensuring you have immediate access to the latest findings before they undergo formal peer review. For each study, we provide both a plain-language explanation to clarify the core concepts and a detailed technical summary for those seeking deeper scientific context. Below are the latest papers in cardiovascular medicine, organized to help you navigate the most recent developments shaping the future of heart health.

📄 cardiovascular medicine

Beyond Agreement: a real-world study of the workflow gap between echocardiography and timely structural cardiac assessmentHow a Validation Study Exposed a Hidden Gap in Cardiac Care

While a prospective study at Cascais Hospital demonstrated that the Cardio-HART (CHART) tool provides clinically credible agreement with echocardiography for left ventricular ejection fraction estimation and heart failure classification, its most significant contribution was revealing a critical, previously overlooked gap between the nominal availability of echocardiography and the timely delivery of structural cardiac assessment in routine care.

Nogueira, M. A., Ferreira, F. C., Batista, E., Eira, S., Proenca, G., Matias, C., Kecskes, I.2026-05-15
📄 cardiovascular medicine

Novel analytical application of the pressure phase plane for evaluating pulmonary artery wave reflection in surgically repaired tetralogy of Fallot

This study demonstrates that pressure phase plane analysis effectively visualizes pulmonary artery wave reflection in surgically repaired tetralogy of Fallot patients, revealing that those who underwent the Rastelli procedure exhibit significantly higher wave reflection and right ventricular afterload compared to other surgical repair types.

Hayabuchi, Y., Homma, Y.2026-05-12
📄 cardiovascular medicine

Causal role of EPA on ischemic heart disease, triglyceride rich lipoproteins and related traits: A two-sample Mendelian randomization analysis

This two-sample Mendelian randomization study suggests that while eicosapentaenoic acid (EPA) remodels triglyceride-rich lipoproteins by shifting particle sizes, it does not demonstrate a protective causal effect against ischemic heart disease in the general European population and may even be associated with a slight increase in risk.

Rasul, R., Schooling, C. M., Soliman, G., Shi, J., Shahn, Z.2026-04-29
📄 cardiovascular medicine

Statistical Analysis Plan for the Cardiac Magnetic Resonance GUIDEd Management of Mild-moderate Left Ventricular Systolic Dysfunction (CMR GUIDE) trial

This paper outlines the pre-specified statistical analysis plan for the CMR GUIDE trial, which aims to evaluate whether implantable cardioverter defibrillators guided by ventricular scar detection reduce sudden cardiac death or significant ventricular arrhythmias in patients with mild-to-moderate left ventricular systolic dysfunction using a Fine and Gray competing risks model.

Billot, L., Gore, J., Atherton, J., Berry, C., Brachmann, J., Ganesan, A., Hillis, G., Jung, W., Prasad, S., Selvanayaga (…)2026-04-28
📄 cardiovascular medicine

Comparative Effectiveness of TTR Stabilizers for the Treatment of ATTR-CM Using Real-World Evidence

This real-world study utilizing US claims data demonstrates that, compared to tafamidis, the newly approved TTR stabilizer acoramidis significantly reduces the risk of diuretic intensification and a composite of diuretic intensification, heart failure hospitalization, and mortality in patients with newly treated ATTR-CM.

Wright, R., Martyn, T., Keshishian, A., Nagelhout, E., Zeldow, B., Udall, M., Lanfear, D., Judge, D. P.2026-04-27
📄 cardiovascular medicine

Myocardial Tug-of-War Is a Determinant of Left Ventricular Function and Failure

This paper introduces the concept of a "myocardial tug-of-war" at the mesoscale, where mechanical interactions between differently contracting myocardial units determine left ventricular efficiency and adaptability in healthy hearts, but contribute to functional decline following myocardial infarction.

Harbo, M. B., Sadeghinia, M. J., Reyes, Y. D. M., Simitev, R. D., Li, J., Blom, K. B., Storas, T. H., Rosseland, V., Klo (…)2026-04-26
📄 cardiovascular medicine

Central Adiposity And Infective Endocarditis: A Cohort Study of UK Biobank Participants

This UK Biobank cohort study of over 386,000 participants reveals that central adiposity, specifically measured by waist circumference and waist-to-height ratio, is a robust independent predictor of incident infective endocarditis, with risk significantly elevated in younger individuals who have both abdominal obesity and diabetes.

Song, W., Zhang, J., Zhipeng, W., Sun, P., Ke, Z., Chenzhen, X., chuanjie, Y., Zhang, Y., Li, L., He, L., Yu, J., Lai, Y (…)2026-04-24
📄 cardiovascular medicine

Postnatal signals for later cardiovascular morbidity after preterm pre-eclampsia

This study demonstrates that women with a history of preterm pre-eclampsia exhibit significant cardiometabolic morbidity, including hypertension and myocardial fibrosis, 3–6 years postpartum, with early postnatal blood pressure, weight, and biomarker profiles serving as predictors for these long-term cardiovascular risks.

Leslie, A., Maadh, S., Lee, M., Jones, O., Priestner, L., Duhig, K., Farrant, J. P., Hutchings, D. C., Naish, J. H., Mil (…)2026-04-22
📄 cardiovascular medicine

Vision Language Model for Coronary Angiogram Analysis and Report Generation: Development and Evaluation Study

This study demonstrates the feasibility of fine-tuning the InternVL2-4B Vision-Language Model to automate coronary angiogram interpretation and report generation, achieving moderate performance in stenosis detection, anatomy labeling, and clinical report synthesis to potentially assist cardiologists in improving diagnostic efficiency and resource-limited care.

Jiang, Q., Ke, Y., Sinisterra, L. G., Elangovan, K., Li, Z., Yeo, K. K., Jonathan, Y., Ting, D. S. W.2026-04-21
📄 cardiovascular medicine

Echocardiographic characterization and markers of cardiovascular risk in adults with sickle cell disease in a Colombian tertiary referral centre: a cross-sectional study

In a cross-sectional study of 57 adults with sickle cell disease in Colombia, echocardiographic analysis revealed that while biventricular structure and function were largely preserved, nearly one-third of patients exhibited signs suggestive of pulmonary hypertension, supporting the routine use of echocardiography for early cardiovascular risk stratification in this population.

Arrieta-Mendoza, M. E., Barbosa-Balaguera, S., Betancourt, J. R., Ayala-Zapata, S., Messu-Llanos, C. D., Rosales-Melo, J (…)2026-04-20